Reliability in fastening depends primarily on material compatibility. Nail screws deliver superior holding power and stability in concrete and masonry by cutting threads into hard, brittle substrates. Self-tapping screws, by contrast, are more reliable for sheet metal, plastics, and wood, forming or cutting threads to achieve strong clamping force and efficient installation. This article compares their design principles, application scenarios, and installation requirements to clarify which fastener offers the most dependable performance in different use cases.